Maryland Route 161 (MD 161) is a state highway in the U.S. state of Maryland. The state highway runs 5.38 miles (8.66 km) from MD 155 in Hopewell Village north to U.S. Route 1 (US 1) in Darlington. MD 161, in conjunction with MD 155, connects Havre de Grace with Susquehanna State Park and northeastern Harford County. The state highway was mostly constructed in the late 1920s and early 1930s.