Emmanuel "Manny" Santo Domingo Lopez (born June 30, 1958) is a Filipino political activist who advocates direct democracy. He is the convenor of such groups as the anti-Bangsamoro Basic Law group that called itself Christian Peace Alliance and the anti-Benigno Aquino III group called EdlSA 2.22.15 Coalition. Previously he formed the EPIRMA, a group of direct democracy advocates. He is currently running for vice president under the Labor Party Philippines in the 2022 Philippine elections.