José Segundo Roca (July 1, 1800 – March 8, 1866) was an Argentine colonel. He took part in the second Upper Peru campaign, and died during the War of the Triple Alliance. He was born in Tucumán, the son of , born in Tarragona, and María Antonia Tejerina, a Creole from Tucumán. He was married to Josefa Agustina Paz, daughter of Juan Bautista de Paz and María Plácida Pereyra, belonging to a distinguished family. He and his wife were the parents of numerous children, including General Julio Argentino Roca, who was twice President of Argentina.