About: Human interactome

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The human interactome is the set of protein–protein interactions (the interactome) that occur in human cells. The sequencing of reference genomes, in particular the Human Genome Project, has revolutionized human genetics, molecular biology, and clinical medicine. Genome-wide association study results have led to the association of genes with most Mendelian disorders, and over 140 000 germline mutations have been associated with at least one genetic disease. However, it became apparent that inherent to these studies is an emphasis on clinical outcome rather than a comprehensive understanding of human disease; indeed to date the most significant contributions of GWAS have been restricted to the “low-hanging fruit” of direct single mutation disorders, prompting a systems biology approach to g

Attributes	Values
rdfs:label	Human interactome (en)
rdfs:comment	The human interactome is the set of protein–protein interactions (the interactome) that occur in human cells. The sequencing of reference genomes, in particular the Human Genome Project, has revolutionized human genetics, molecular biology, and clinical medicine. Genome-wide association study results have led to the association of genes with most Mendelian disorders, and over 140 000 germline mutations have been associated with at least one genetic disease. However, it became apparent that inherent to these studies is an emphasis on clinical outcome rather than a comprehensive understanding of human disease; indeed to date the most significant contributions of GWAS have been restricted to the “low-hanging fruit” of direct single mutation disorders, prompting a systems biology approach to g (en)
dcterms:subject	Molecular biology Human genetics Systems biology
Wikipage page ID	45663583 (xsd:integer)
Wikipage revision ID	1064771281 (xsd:integer)
Link from a Wikipage to another Wikipage	Caenorhabditis elegans Monogenetic BioGRID Human proteome project Interactome Mass spectrometry Network topology Protein–protein interaction Protein–protein interaction prediction Proteome Neurodegeneration Gene co-expression network Gene expression Gene regulatory network Genome-wide association study Genotype Gene ontology Clinical medicine Colocalization Complex traits Protein structure Tandem affinity purification The Cancer Genome Atlas Autism Förster resonance energy transfer Molecular biology Database Drosophila False positives and false negatives Human genetics Rosalind (education) High-throughput screening Signal transduction Yeast Model organism Systems biology Phenotype Phylogenetic tree Human Genome Project Human genetics Cancer systems biology Molecular biology Two-hybrid screening Protein–protein interactions
sameAs	Human interactome Human interactome Human interactome
dbp:wikiPageUsesTemplate	dbt:Lead_rewrite dbt:Reflist dbt:Use_dmy_dates
has abstract	The human interactome is the set of protein–protein interactions (the interactome) that occur in human cells. The sequencing of reference genomes, in particular the Human Genome Project, has revolutionized human genetics, molecular biology, and clinical medicine. Genome-wide association study results have led to the association of genes with most Mendelian disorders, and over 140 000 germline mutations have been associated with at least one genetic disease. However, it became apparent that inherent to these studies is an emphasis on clinical outcome rather than a comprehensive understanding of human disease; indeed to date the most significant contributions of GWAS have been restricted to the “low-hanging fruit” of direct single mutation disorders, prompting a systems biology approach to genomic analysis. The connection between genotype and phenotype (how variation in genotype affects the disease or normal functioning of the cell and the human body) remain elusive, especially in the context of multigenic complex traits and cancer. To assign functional context to genotypic changes, much of recent research efforts have been devoted to the mapping of the networks formed by interactions of cellular and genetic components in humans, as well as how these networks are altered by genetic and somatic disease. (en)
gold:hypernym	Set
prov:wasDerivedFrom	wikipedia-en:Human_interactome?oldid=1064771281&ns=0
page length (characters) of wiki page	22513 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Human_interactome
is Link from a Wikipage to another Wikipage of	Interactome Protein–protein interaction
is foaf:primaryTopic of	wikipedia-en:Human_interactome

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