The Church of the Holy Cross (1803-ca.1862) was located on Franklin Street in Boston, Massachusetts. In 1808 the church became the Cathedral of the Holy Cross. It was designed by Charles Bulfinch and was the first church built for the city's Roman Catholics. The last Mass was celebrated there on September 16, 1860. Demolition took place around 1862. The cathedral was replaced by a new Cathedral of the Holy Cross located in the South End.