The Hanover–Brunswick Railway is a German main line railway in Lower Saxony and is one of the oldest lines in Germany, opened in 1843 and 1844. It was the first railway line linking to the city of Hanover and the first operating line of the Royal Hanoverian State Railways (German: Königlich Hannöversche Staatseisenbahnen). It is now one of the main routes for east-west traffic. The main intermediate station is Peine.