Hampden Coit DuBose (30 September 1845 in Darlington, South Carolina – 22 March 1910 in Suzhou) was a Presbyterian missionary in China with the American Presbyterian Mission (South) and founder of the . Rev. Dr. Hampden Coit DuBose was the son of Rev. Julius Jesse DuBose and Margaret Eliza Thompson, married Pauline McAlpine, daughter of Augustine Irving McAlpine and Martha Clisby and had seven children with her.