Gustave F. Perna (born 1960) is a retired United States Army four-star general who last served as the chief operating officer of the federal COVID-19 response for vaccine and therapeutics. He previously served as the chief operating officer of Operation Warp Speed from July 2020 until the operation's duties and responsibilities were transferred to the White House COVID-19 Response Team in February 2021. As chief operating officer of COVID-19 response, he oversaw the logistics in the United States federal government's distribution of the vaccine to the COVID-19 pandemic. The Senate confirmed his nomination as chief operating officer on July 2, 2020, and he assumed the office shortly after.