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Granulomatous meningoencephalitis (GME) is an inflammatory disease of the central nervous system (CNS) of dogs and, rarely, cats. It is a form of meningoencephalitis. GME is likely second only to encephalitis caused by canine distemper virus as the most common cause of inflammatory disease of the canine CNS. The disease is more common in female dogs of young and middle age. It has a rapid onset. The lesions of GME exist mainly in the white matter of the cerebrum, brainstem, cerebellum, and spinal cord. The cause is only known to be noninfectious and is considered at this time to be idiopathic. Because lesions resemble those seen in allergic meningoencephalitis, GME is thought to have an immune-mediated cause, but it is also thought that the disease may be based on an abnormal response to a

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  • Granulomatöse Meningoenzephalitis (de)
  • Meningoencefalitis granulomatosa (es)
  • Granulomatous meningoencephalitis (en)
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  • Die Granulomatöse Meningoenzephalitis ist eine bei Haushunden gelegentlich vorkommende, weltweit verbreitete Entzündung der Hirnhaut und des Gehirns (Meningoenzephalitis). Betroffen sind in Europa vor allem Hunde mittleren bis hohen Alters. (de)
  • Granulomatous meningoencephalitis (GME) is an inflammatory disease of the central nervous system (CNS) of dogs and, rarely, cats. It is a form of meningoencephalitis. GME is likely second only to encephalitis caused by canine distemper virus as the most common cause of inflammatory disease of the canine CNS. The disease is more common in female dogs of young and middle age. It has a rapid onset. The lesions of GME exist mainly in the white matter of the cerebrum, brainstem, cerebellum, and spinal cord. The cause is only known to be noninfectious and is considered at this time to be idiopathic. Because lesions resemble those seen in allergic meningoencephalitis, GME is thought to have an immune-mediated cause, but it is also thought that the disease may be based on an abnormal response to a (en)
  • La meningoencefalitis granulomatosa o meningoencefalomielitis granulomatosa (MEG) es una enfermedad inflamatoria del sistema nervioso central (SNC) de perros y, raramente, de gatos. Es una forma de meningoencefalitis no infecciosa. Puede afectar a cualquier raza de perro, sin embargo es más prevalente en razas pequeñas como los terriers.​ (es)
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  • Die Granulomatöse Meningoenzephalitis ist eine bei Haushunden gelegentlich vorkommende, weltweit verbreitete Entzündung der Hirnhaut und des Gehirns (Meningoenzephalitis). Betroffen sind in Europa vor allem Hunde mittleren bis hohen Alters. (de)
  • Granulomatous meningoencephalitis (GME) is an inflammatory disease of the central nervous system (CNS) of dogs and, rarely, cats. It is a form of meningoencephalitis. GME is likely second only to encephalitis caused by canine distemper virus as the most common cause of inflammatory disease of the canine CNS. The disease is more common in female dogs of young and middle age. It has a rapid onset. The lesions of GME exist mainly in the white matter of the cerebrum, brainstem, cerebellum, and spinal cord. The cause is only known to be noninfectious and is considered at this time to be idiopathic. Because lesions resemble those seen in allergic meningoencephalitis, GME is thought to have an immune-mediated cause, but it is also thought that the disease may be based on an abnormal response to an infectious agent. One study searched for viral DNA from canine herpesvirus, canine adenovirus, and canine parvovirus in brain tissue from dogs with GME, necrotizing meningoencephalitis, and necrotizing leukoencephalitis (see below for the latter two conditions), but failed to find any. (en)
  • La meningoencefalitis granulomatosa o meningoencefalomielitis granulomatosa (MEG) es una enfermedad inflamatoria del sistema nervioso central (SNC) de perros y, raramente, de gatos. Es una forma de meningoencefalitis no infecciosa. Puede afectar a cualquier raza de perro, sin embargo es más prevalente en razas pequeñas como los terriers.​ La enfermedad es más común en hembras cachorras. Es de rápida aparición. Las lesiones de la MEG están mayormente en la materia blanca del telencéfalo, espina dorsal, cerebelo, y médula espinal.​ No se ha descubierto una causa infecciosa y es considerada como idiopática. Debido a que las lesiones recuerdan aquellas de la meningoencefalitis alérgica, la MEG es tomada como una enfermedad inmune, pero también es considerada una respuesta anormal frente a un agente infeccioso.​ Un estudio sobre el ADN viral del , (hepatitis por adenovirus canino), y parvovirus canino en tejido cerebral de perros con MEG, con meningoencefalitis necrotizante, y leucoencefalitis necrotizante (ver abajo para las dos condiciones ulteriores), falló en encontrar alguna relación.​ (es)
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