About: DNA-binding domain

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A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA. A DBD can recognize a specific DNA sequence (a recognition sequence) or have a general affinity to DNA. Some DNA-binding domains may also include nucleic acids in their folded structure.

Attributes	Values
rdf:type	Thing yago:WikicatTranscriptionFactors yago:Abstraction100002137 yago:Beginning107290905 yago:Cause107326557 yago:Chemical114806838 yago:Compound114818238 yago:Event100029378 yago:Factor107327805 yago:Happening107283608 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Origin107323922 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:PsychologicalFeature100023100 yago:Relation100031921 yago:YagoPermanentlyLocatedEntity yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteins
rdfs:label	Dominio de unión al ADN (es) DNA-binding domain (en) Domaine de liaison à l'ADN (fr) DNA 결합 도메인 (ko) DNA結合ドメイン (ja) DNA-bindingsdomein (nl)
rdfs:comment	Un dominio de unión al ADN (en inglés, DBD, siglas de DNA-binding domain) es un dominio proteico (una zona de la proteína) plegado independientemente que contiene al menos un motivo estructural que reconoce hebras de ADN dobles o simples. Un dominio de unión al ADN puede reconocer una secuencia específica de ADN (una secuencia de reconocimiento) o tener una afinidad general hacia el ácido desoxirribonucleico (ADN). Algunos dominios de unión al ADN pueden incluir ácidos nucléicos en su estructura. (es) A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA. A DBD can recognize a specific DNA sequence (a recognition sequence) or have a general affinity to DNA. Some DNA-binding domains may also include nucleic acids in their folded structure. (en) Un domaine de liaison à l'ADN (ou DBD de l'anglais DNA-binding domain) est un motif protéique qui est capable de lier à l'ADN double ou simple brin avec une affinité pour une séquence nucléotidique spécifique, ou une affinité relative à l'ADN. Les domaines de liaison à l'ADN sont présents dans de nombreuses protéines impliquées dans la régulation de l'expression des gènes (comme les facteurs de transcription). Il existe de nombreux types de DBD caractérisant des familles de protéines. (fr) Een DNA-bindingsdomein of DBD (Engels: DNA-binding domain) is een onafhankelijk gevouwen eiwitdomein met ten minste één motief dat dubbel- of enkelstrengs-DNA herkent. Een DNA-bindingsdomein herkent een specifieke DNA-sequentie of heeft een algemene affiniteit tot DNA. In sommige DNA-bindingsdomeinen kunnen in de gevouwen structuur ook nucleïnezuren voorkomen. (nl) DNA結合ドメイン（DNA-binding domain： DBD）とは、二本鎖または一本鎖DNAを認識する少なくとも1つの構造モチーフを構造に含むタンパク質ドメインである。DBDは特定のDNA配列（認識配列）に対して特異的な、またはDNA一般に対して親和性を持つ。一部のDNA結合ドメインは、折り畳まれた構造の核酸も含む。 (ja) DNA 결합 도메인(DNA Binding Domain, DBD)은 이중 또는 단일 가닥 DNA를 인식하는 하나 이상의 구조적 모티프를 포함하는 독립적으로 접힌 단백질 도메인이다. DNA 결합 도메인은 특정 DNA 서열을 인식하거나 DNA에 대한 일반적인 친화성을 가질 수 있다. 일부 DNA 결합 도메인은 접힌 구조에 핵산을 포함할 수도 있다. 하나 이상의 DNA 결합 도메인은 종종 기능이 다른 추가 단백질 도메인으로 구성된 더 큰 단백질의 일부이다. 종종 여분의 도메인은 DNA 결합 도메인의 활성을 조절한다. DNA 결합의 기능은 구조적이거나 전사 조절을 포함하며 두 역할이 때때로 겹치기도 한다. DNA 구조를 포함하는 기능을 가진 DNA 결합 도메인은 DNA 복제, DNA 수선, 저장, DNA 메틸화와 같은 변형에 생물학적 역할을 한다. 유전자 발현의 조절에 관여하는 많은 단백질은 DNA 결합 도메인을 포함한다. 예를 들어, DNA와 결합함으로써 전사를 조절하는 단백질은 전사인자라고 불린다. 대부분의 세포 신호 캐스케이드의 최종 산출물은 유전자 조절이다. (ko)
rdfs:seeAlso	DNA-binding protein
foaf:depiction
dcterms:subject	Molecular genetics Protein domains
Wikipage page ID	3200477 (xsd:integer)
Wikipage revision ID	1114356414 (xsd:integer)
Link from a Wikipage to another Wikipage	Caenorhabditis elegans Electron paramagnetic resonance Mutation Structural motif Basic helix-loop-helix Hydrogen bond Beta sheet DNA DNA-binding protein DNA footprinting DNA methylation DNA repair DNA replication Molecular geometry Saccharomyces cerevisiae Leucine zipper Molecular genetics Gel electrophoresis Genetic recombination Oligonucleotide Oligosaccharide Enzyme Cross-link Arabidopsis thaliana Leucine Calorimetry Single-stranded binding protein Comparison of nucleic acid simulation software dbr:Deoxyribonuclease_I Protein structure TAL effector Microscale thermophoresis B3 domain Transcription (biology) Drosophila melanogaster Alpha helix PROSITE Chromatin Protein domain Transcription factor Molecular recognition Protein Regulation of gene expression Restriction enzyme Protein domains HMG-box Helix-turn-helix BZIP domain Telomere Cold shock response Tertiary structure Translation (biology) Zinc finger Recognition sequence

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