DARPins (an acronym for designed ankyrin repeat proteins) are genetically engineered antibody mimetic proteins typically exhibiting highly specific and high-affinity target protein binding. They are derived from natural ankyrin repeat proteins, one of the most common classes of binding proteins in nature, which are responsible for diverse functions such as cell signaling, regulation and structural integrity of the cell. DARPins consist of at least three, repeat motifs or modules, of which the most N- and the most C-terminal modules are referred to as "caps", since they shield the hydrophobic core of the protein. The number of internal modules is indicated as number (e.g. N1C, N2C, N3C, ...) while the caps are indicated with "N" or "C", respectively. The molecular mass of e.g. 14 or 18 kDa
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| - DARPins (kurz von engl. Designed Ankyrin Repeat Proteins) sind künstliche Proteine, die zur Erkennung und Bindung von Antigenen befähigt sind. Sie sind strukturell von Ankyrin-Proteinen abgeleitet und bestehen aus mehreren Repeat-Motiven dieser Proteine. DARPins mit insgesamt vier Repeat-Motiven und einer Molekülmasse von etwa 14 kDa sind etwa 10-mal leichter als ein Antikörper vom IgG-Typ. Ihre Affinität zu einem Antigen ist mit der eines Antikörpers vergleichbar. DARPins können sich als Agonisten, Antagonisten, inverse Agonisten oder Enzyminhibitoren verhalten. DARPins wurden maßgeblich an der Universität Zürich entwickelt. Ein Einsatz als Werkzeuge in der Forschung sowie als Diagnostika und Therapeutika wird angestrebt. (de)
- DARPins (an acronym for designed ankyrin repeat proteins) are genetically engineered antibody mimetic proteins typically exhibiting highly specific and high-affinity target protein binding. They are derived from natural ankyrin repeat proteins, one of the most common classes of binding proteins in nature, which are responsible for diverse functions such as cell signaling, regulation and structural integrity of the cell. DARPins consist of at least three, repeat motifs or modules, of which the most N- and the most C-terminal modules are referred to as "caps", since they shield the hydrophobic core of the protein. The number of internal modules is indicated as number (e.g. N1C, N2C, N3C, ...) while the caps are indicated with "N" or "C", respectively. The molecular mass of e.g. 14 or 18 kDa (en)
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| - DARPins (kurz von engl. Designed Ankyrin Repeat Proteins) sind künstliche Proteine, die zur Erkennung und Bindung von Antigenen befähigt sind. Sie sind strukturell von Ankyrin-Proteinen abgeleitet und bestehen aus mehreren Repeat-Motiven dieser Proteine. DARPins mit insgesamt vier Repeat-Motiven und einer Molekülmasse von etwa 14 kDa sind etwa 10-mal leichter als ein Antikörper vom IgG-Typ. Ihre Affinität zu einem Antigen ist mit der eines Antikörpers vergleichbar. DARPins können sich als Agonisten, Antagonisten, inverse Agonisten oder Enzyminhibitoren verhalten. DARPins wurden maßgeblich an der Universität Zürich entwickelt. Ein Einsatz als Werkzeuge in der Forschung sowie als Diagnostika und Therapeutika wird angestrebt. (de)
- DARPins (an acronym for designed ankyrin repeat proteins) are genetically engineered antibody mimetic proteins typically exhibiting highly specific and high-affinity target protein binding. They are derived from natural ankyrin repeat proteins, one of the most common classes of binding proteins in nature, which are responsible for diverse functions such as cell signaling, regulation and structural integrity of the cell. DARPins consist of at least three, repeat motifs or modules, of which the most N- and the most C-terminal modules are referred to as "caps", since they shield the hydrophobic core of the protein. The number of internal modules is indicated as number (e.g. N1C, N2C, N3C, ...) while the caps are indicated with "N" or "C", respectively. The molecular mass of e.g. 14 or 18 kDa (kilodaltons) for four- (N2C) or five- (N3C) repeat DARPins is rather small for a biologic (ca 10% of the size of an IgG). DARPins constitute a new class of potent, specific and versatile small-protein therapeutics, and are used as investigational tools in various research, diagnostic and therapeutic applications. Molecular Partners AG, a clinical-stage biopharmaceutical company with several DARPin molecules in clinical and preclinical development, is currently pursuing the own development of therapeutic DARPins (forward integration). Athebio AG builds on further improving the DARPin scaffold for a partnering model approach. In addition, DARPins can be used as crystallization chaperones for soluble and membrane proteins, including G protein-coupled receptors (GPCRs), either as binding partners or as rigid fusions to the target protein. (en)
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