The Chena River (/ˈtʃiːnə/; Tanana Athabascan: Ch'eno' "river of something (game)") is a 100-mile (160 km) tributary of the Tanana River in the Interior region of the U.S. state of Alaska. It flows generally west from the White Mountains to the Tanana River near the city of Fairbanks, which is built on both sides of the river. The Tanana empties into the 2,300-mile (3,700 km) long Yukon River.