About: Cdc6

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Cdc6, or cell division cycle 6, is a protein in eukaryotic cells. It is mainly studied in the budding yeast Saccharomyces cerevisiae (P09119). It is an essential regulator of DNA replication and plays important roles in the activation and maintenance of the checkpoint mechanisms in the cell cycle that coordinate S phase and mitosis. It is part of the pre-replicative complex (pre-RC) and is required for loading minichromosome maintenance (MCM) proteins onto the DNA, an essential step in the initiation of DNA synthesis. In addition, it is a member of the family of AAA+ ATPases and highly related to ORC1; both are the same protein in archaea.

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteins umbel-rc:ProteinMolecule
rdfs:label	Cdc6 (en) Cdc6 (es)
rdfs:comment	Cdc6, or cell division cycle 6, is a protein in eukaryotic cells. It is mainly studied in the budding yeast Saccharomyces cerevisiae (P09119). It is an essential regulator of DNA replication and plays important roles in the activation and maintenance of the checkpoint mechanisms in the cell cycle that coordinate S phase and mitosis. It is part of the pre-replicative complex (pre-RC) and is required for loading minichromosome maintenance (MCM) proteins onto the DNA, an essential step in the initiation of DNA synthesis. In addition, it is a member of the family of AAA+ ATPases and highly related to ORC1; both are the same protein in archaea. (en) El Cdc6 es un regulador esencial de la replicación del ADN y juega un papel importante en la activación y el mantenimiento de los mecanismos de control en el ciclo celular que coordinan la fase S y la mitosis. Es parte del complejo pre-replicativo (pre-RC) y es necesario para la carga de mantenimiento de cromosomas Mini (MCM) las proteínas en el ADN, un paso esencial en la iniciación de la síntesis de ADN. Además, es miembro de la familia de la AAA + ATPasas y altamente asociado con el Orc1p. * Datos: Q5055656 (es)
name	Cdc6/Orc1, C-terminal (en) Cell division protein Cdc6/18 (en) Orc1/Cdc6-type DNA replication protein, archaea (en)
foaf:depiction
dcterms:subject	Saccharomyces cerevisiae DNA replication Fungal proteins
Wikipage page ID	19658026 (xsd:integer)
Wikipage revision ID	1108422658 (xsd:integer)
Link from a Wikipage to another Wikipage	Proteasome Electron microscope ORC1 Saccharomyces cerevisiae DNA replication CDC28 protein kinase CDC6 Saccharomyces cerevisiae P14arf Pre-replication complex Pyrobaculum aerophilum Archaea Lung cancer Prostate cancer Cervical cancer Adenosine triphosphate Eukaryotic Cell cycle Chromatin Epigenetic Protein DNA replication AAA proteins Mitosis Fungal proteins Minichromosome maintenance S phase Ageing Oncogene X-ray scattering techniques Origin Recognition Complex Phosphorylate Brain cancer Cdc28 Cdt1 Ubiquitinylation
Link from a Wikipage to an external page	https://archive.today/20121228083815/http:/db.yeastgenome.org/cgi-bin/locus.pl%3Flocus=YJL194W
sameAs	Cdc6 Cdc6 Cdc6 Cdc6 Cdc6 Cdc6 Cdc6
dbp:wikiPageUsesTemplate	dbt:UniProt dbt:Reflist dbt:PDB dbt:Pfam_box dbt:DNA_replication
thumbnail	wiki-commons:Special:FilePath/Cdc6.png?width=300
caption	Crystal Structure of CDC6 from P. aerophilum . Green and blue domains are AAA domains; red domain is the Cdc6 C-terminal HTH domain . (en)
InterPro	IPR014277 (en) IPR015163 (en) IPR016314 (en)
Pfam	PF09079 (en)
symbol	Cdc6 (en) Cdc6_C (en) Orc1/Cdc6_arc (en)
width	125 (xsd:integer)
has abstract	Cdc6, or cell division cycle 6, is a protein in eukaryotic cells. It is mainly studied in the budding yeast Saccharomyces cerevisiae (P09119). It is an essential regulator of DNA replication and plays important roles in the activation and maintenance of the checkpoint mechanisms in the cell cycle that coordinate S phase and mitosis. It is part of the pre-replicative complex (pre-RC) and is required for loading minichromosome maintenance (MCM) proteins onto the DNA, an essential step in the initiation of DNA synthesis. In addition, it is a member of the family of AAA+ ATPases and highly related to ORC1; both are the same protein in archaea. (en) El Cdc6 es un regulador esencial de la replicación del ADN y juega un papel importante en la activación y el mantenimiento de los mecanismos de control en el ciclo celular que coordinan la fase S y la mitosis. Es parte del complejo pre-replicativo (pre-RC) y es necesario para la carga de mantenimiento de cromosomas Mini (MCM) las proteínas en el ADN, un paso esencial en la iniciación de la síntesis de ADN. Además, es miembro de la familia de la AAA + ATPasas y altamente asociado con el Orc1p. * Datos: Q5055656 (es)
CDD	cd08768 (en)

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