The 2022 Houston Cougars football team represents the University of Houston in the 2022 NCAA Division I FBS football season. The Cougars play their home games at TDECU Stadium in Houston, Texas, competing in the American Athletic Conference (The American). They are led by 4th-year head coach Dana Holgorsen. In September 2021, Houston and fellow conference members Cincinnati and UCF accepted bids to join the Big 12 Conference. The schools had been contractually required to remain with The American through 2024, but all reached a separation agreement that will allow them to join the Big 12 in 2023. Accordingly, the 2022 season will be the program's last season as a member of The American.