The 2021 season was the 107th in Remo's existence. This season Remo participated in the Campeonato Brasileiro Série B, the Campeonato Paraense, Copa Verde and the Copa do Brasil. Remo finished the Campeonato Brasileiro Série B in the 17th place, and was relegated to the Série C. In the Campeonato Paraense, the club was eliminated in the semifinals to Tuna Luso and finished in 3rd place after beating Castanhal 3–0 in the third place match. In the Copa Verde, Remo won the unprecedented title in an undefeated way after beating Vila Nova on penalties. The team played seven games, winning three and drawing four. In the Copa do Brasil, Remo was eliminated in the third round by Atlético Mineiro.