The 2021–22 Syed Mushtaq Ali Trophy was the fourteenth season of the Syed Mushtaq Ali Trophy, a Twenty20 cricket tournament played in India. It was contested by 38 teams, divided into six groups, with six teams in Group E. The tournament was announced by BCCI on 3 July 2021. Hyderabad won all five of their matches, with Saurashtra winning four matches. Therefore, Hyderabad advanced to the quarter-finals and Saurashtra progressed to the preliminary quarter-finals.