The 2021–22 Mount St. Mary's Mountaineers women's basketball team represented Mount St. Mary's University in the 2021–22 NCAA Division I women's basketball season. The Mountaineers, led by first-year head coach , played their home games at Knott Arena in Emmitsburg, Maryland as members of the Northeast Conference. On May 2, 2022, it was announced that the Mountaineers will join the MAAC on July 1, 2022, leaving the NEC where they had been members since 1989.