The 2021–22 Milwaukee Panthers men's basketball team represented the University of Wisconsin–Milwaukee during the 2021–22 NCAA Division I men's basketball season. The Panthers, led by fifth-year head coach Pat Baldwin, played their home games at the UW–Milwaukee Panther Arena as members of the Horizon League. They finished the season 10–21, 8–14 in Horizon League play to finish in ninth place. They lost in the first round of the Horizon League Tournament to UIC.