The 2021–22 Cleveland State Vikings men's basketball team represented Cleveland State University in the 2021–22 NCAA Division I men's basketball season. The Vikings, led by third-year head coach Dennis Gates, played their home games at the Wolstein Center in Cleveland, Ohio as members of the Horizon League. They finished the season 20–11, 15–6 in Horizon League play to earn a share of the regular season championship for the second consecutive year. As the No. 1 seed in the Horizon League tournament, they defeated Robert Morris in the quarterfinals before losing to Wright State in the semifinals. As a regular season champion that did not win their conference tournament, they received an automatic bid to the National Invitation Tournament. They lost in the first round of the NIT to Xavier.