The 2019 Southeast Missouri State Redhawks football team represented Southeast Missouri State University as a member of the Ohio Valley Conference (OVC) during the 2019 NCAA Division I FCS football season. Led by sixth-year head coach Tom Matukewicz, the Redhawks compiled an overall record of 9–4 with a mark of 7–1 in conference play, sharing the OVC title with Austin Peay. Southeast Missouri State received an at-large bid to the NCAA Division I Football Championship playoffs, where the Redhawks lost to Illinois State in the first round. The team played home games at Houck Stadium in Cape Girardeau, Missouri.