The 2019 Eastern Illinois Panthers football team represented Eastern Illinois University as a member of the Ohio Valley Conference (OVC) during the 2019 NCAA Division I FCS football season. Led by first-year head coach Adam Cushing, the Panthers compiled an overall record of 1–11 overall with a mark of 1–7 in conference play, placing last out of nine teams in the OVC. Eastern Illinois played home games at O'Brien Field in Charleston, Illinois.