The 2018 McNeese State Cowboys football team represented McNeese State University in the 2018 NCAA Division I FCS football season. The Cowboys were led by third-year head coach Lance Guidry and played their home games at Cowboy Stadium. They were a member of the Southland Conference. They finished the season 6–5, 5–4 in Southland play to finish in a four-way tie for fourth place. On November 20, head coach Lance Guidry was fired. He finished at McNeese State with a three-year record of 21–12.