The 2018 Louisville Cardinals football team represented the University of Louisville during the 2018 NCAA Division I FBS football season. The Cardinals competed in the Atlantic Division of the Atlantic Coast Conference. They played their home games at Cardinal Stadium (previously Papa John's Cardinal Stadium) in Louisville, Kentucky. They were led by head coach Bobby Petrino until he was fired on November 11 after starting the season 2–8. Lorenzo Ward was the interim head coach for the remainder of the season. They finished the season 2–10, 0–8 in ACC play to finish in last place in the Atlantic Division.