The 2018 Buffalo Bulls football team represented the University at Buffalo in the 2018 NCAA Division I FBS football season. The Bulls were led by fourth-year head coach Lance Leipold and played their home games at the University at Buffalo Stadium as members of the East Division of the Mid-American Conference. They finished the season 10–4, 7–1 in MAC play to be champions of the East Division. They represented the East Division in the MAC Championship Game where they lost to West Division champion Northern Illinois. They were invited to the Dollar General Bowl where they lost to Troy. Their 10 wins are the most in program history with the previous best being eight wins set in 2008.