The 2018–19 Duke Blue Devils women's basketball team will represent Duke University during the 2018–19 NCAA Division I women's basketball season. Returning as head coach was Joanne P. McCallie entering her 12th season. The team plays its home games at Cameron Indoor Stadium in Durham, North Carolina as members of the Atlantic Coast Conference. They finished the season 15–15, 6–10 in ACC play to finish in a tie for tenth place. They advanced to the second round of the ACC women's tournament where they lost to Florida State.