The 2015–16 Wyoming Cowboys basketball team represented the University of Wyoming during the 2015–16 NCAA Division I men's basketball season. Their head coach was Larry Shyatt in his sixth and final year, including his first tenure in 1998. Shyatt resigned at the end of the year to take a job in the NBA. They played their home games at the Arena-Auditorium in Laramie, Wyoming. The Cowboys were a member of the Mountain West Conference. They finished the season 14–18, 7–11 in Mountain West play to finish in a tie for eighth place. They lost in the first round of the Mountain West tournament to Utah State.