The 2015–16 Topklasse season was the sixth and last edition of the Dutch third tier since its inauguration in the current form in 2010. A total 32 teams participated in the league: 25 from the 2014–15 Topklasse, and the remaining seven from the 2014–15 Hoofdklasse. As usual, the competition was divided into two leagues: "Saturday" and "Sunday", who differed by the day their games were usually played.