The 2015–16 Oklahoma Sooners women's basketball team will represent the University of Oklahoma in the 2015–16 NCAA Division I women's basketball season. The Sooners are led by Sherri Coale in her twentieth season. The team will play its home games at the Lloyd Noble Center in Norman, Oklahoma as a member of the Big 12 Conference. They finished the season 22–11, 11–7 in Big 12 play to finish in a tie for fourth place. They advanced to the semifinals of the where they lost to Baylor. They received at-large bid of the NCAA women's tournament where they defeated Purdue in the first round before losing to Kentucky in the second round.