The 2015–16 Iowa State Cyclones women's basketball team represented Iowa State University in the 2015–16 NCAA Division I women's basketball season. This was head coach Bill Fennelly's 21st season at Iowa State. The Cyclones were members of the Big 12 Conference and played their home games at the Hilton Coliseum. They finished the season 13–17, 5–13 in Big 12 play to finish in eighth place. They lost in the first round of the Big 12 women's tournament to Texas Tech.