The 2010 UST Growling Tigers men's basketball team represented University of Santo Tomas in the 73rd season of the University Athletic Association of the Philippines. The men's basketball tournament for the school year 2010-11 began on July 10, 2010 and the host school for the season was De La Salle University. UST finished seventh at the end of the double round-robin eliminations. They won four games against ten losses, giving head coach Pido Jarencio his worst win–loss record in the UAAP. They had an average winning margin of 3.0 points and an average losing margin of 7.7 points.