About: 2-Aminoethoxydiphenyl borate     Goto   Sponge   NotDistinct   Permalink

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2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations). In research it is used to manipulate intracellular release of calcium ions (Ca2+) and modify TRP channel activity, although the lack of specific effects make it less than ideal under some circumstances. Additionally, there is evidence that 2-APB acts directly to inhibit gap junctions made of connexin. Increasing evidence showed that 2-APB is a powerful modifier of store-operated calcium channels (SOC) function, low concentration of 2-APB can enhance SOC while high concentration induces a transient increase followed by complete inhibition.

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  • 2-Aminoethoxydiphenyl borate
  • ジフェニルボリン酸2-アミノエチル
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  • 2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations). In research it is used to manipulate intracellular release of calcium ions (Ca2+) and modify TRP channel activity, although the lack of specific effects make it less than ideal under some circumstances. Additionally, there is evidence that 2-APB acts directly to inhibit gap junctions made of connexin. Increasing evidence showed that 2-APB is a powerful modifier of store-operated calcium channels (SOC) function, low concentration of 2-APB can enhance SOC while high concentration induces a transient increase followed by complete inhibition.
  • ジフェニルボリン酸2-アミノエチル(2-Aminoethoxydiphenyl borate; 2-APB)は、イノシトールトリスリン酸受容体との阻害剤である。これに加えてコネクシン26や32から成るギャップ結合を直接阻害することが知られている。またの機能に強く影響することが示されており、低濃度では促進し、高濃度では一過的に促進したのち阻害に転ずる。
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  • 2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations). In research it is used to manipulate intracellular release of calcium ions (Ca2+) and modify TRP channel activity, although the lack of specific effects make it less than ideal under some circumstances. Additionally, there is evidence that 2-APB acts directly to inhibit gap junctions made of connexin. Increasing evidence showed that 2-APB is a powerful modifier of store-operated calcium channels (SOC) function, low concentration of 2-APB can enhance SOC while high concentration induces a transient increase followed by complete inhibition.
  • ジフェニルボリン酸2-アミノエチル(2-Aminoethoxydiphenyl borate; 2-APB)は、イノシトールトリスリン酸受容体との阻害剤である。これに加えてコネクシン26や32から成るギャップ結合を直接阻害することが知られている。またの機能に強く影響することが示されており、低濃度では促進し、高濃度では一過的に促進したのち阻害に転ずる。
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  • Diphenylborinic acid 2-aminoethyl ester
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  • Diphenylborinic acid 2-aminoethyl ester
  • 2-Aminoethyl diphenyl borate
  • 2-Aminoethyl diphenylborinate
IUPAC name
  • 2-[(Diphenylboranyl)oxy]ethan-1-amine
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