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About: 2-Aminoethoxydiphenyl borate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:ChemicalSubstanceType, within Data Space : dbpedia.org associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceChemical compoundyago:WikicatAromaticCompoundsyago:WikicatMolecularFormulasyago:WikicatOrganoboronCompoundsyago:Abstraction100002137yago:AromaticCompound114610088yago:Chemical114806838yago:Cognition100023271yago:Communication100033020yago:Compound105870180yago:Compound114818238yago:Concept105835747yago:Content105809192yago:Formula106816935yago:Hydrocarbon114911057yago:Idea105833840yago:Material114580897yago:Matter100020827yago:Message106598915yago:MolecularFormula106817173yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:PsychologicalFeature100023100yago:Relation100031921chemical compoundyago:Statement106722453yago:Substance100019613yago:Whole105869584umbel-rc:ChemicalSubstanceType New Facet based on Instances of this Class

2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations). In research it is used to manipulate intracellular release of calcium ions (Ca2+) and modify TRP channel activity, although the lack of specific effects make it less than ideal under some circumstances. Additionally, there is evidence that 2-APB acts directly to inhibit gap junctions made of connexin. Increasing evidence showed that 2-APB is a powerful modifier of store-operated calcium channels (SOC) function, low concentration of 2-APB can enhance SOC while high concentration induces a transient increase followed by complete inhibition.