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About: Xiaodong Wang (biochemist)     Goto   Sponge   NotDistinct   Permalink

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Type: Thingfoaf:Personpersondul:NaturalPersonEukaryotePersonHumanAnimalanimaleukaryotescientistspeciesschema:PersonScientist New Facet based on Instances of this Class

Xiaodong Wang (simplified Chinese: 王晓东; traditional Chinese: 王曉東; pinyin: Wāng Xiǎodōng, born 1963) is a Chinese biochemist best known for his work with cytochrome c. His laboratory developed an in vitro assay for the activation of the apoptosis related proteinase Caspase-3. This allowed the biochemical purification of a complex of Cytochrome c, Caspase-9 and the Apoptotic Protease Activating factor-1 (APAF1). These components are essential for forming a ternary complex called the apoptosome that activates Caspase-3 downstream of the intracellular or mitochondrial pathway of apoptosis.