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About: Toxic unit     Goto   Sponge   NotDistinct   Permalink

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Toxic units (TU) are used in the field of toxicology to quantify the interactions of toxicants in binary mixtures of chemicals. A toxic unit for a given compound is based on the concentration at which there is a 50% effect (ex. EC50) for a certain biological endpoint. One toxic unit is equal to the EC50 for a given endpoint for a specific biological effect over a given amount of time. Toxic units allow for the comparison of the individual toxicities of a binary mixture to the combined toxicity. This allows researchers to categorize mixtures as additive, synergistic or antagonistic. Synergism and antagonism are defined by mixtures that are more or less toxic than predicted by the sum of their toxic units.