In pharmacology, Schild regression analysis, named for Heinz Otto Schild, is a tool for studying the effects of agonists and antagonists on the response caused by the receptor or on ligand-receptor binding. where
* r is the dose ratio
* is the concentration of the antagonist
* is the equilibrium constant of the binding of the antagonist to the receptor A Schild plot is a double logarithmic plot, typically as the ordinate and as the abscissa. This is done by taking the base-10 logarithm of both sides of the previous equation after subtracting 1:
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| - Schild-Plot (de)
- シルトプロット (ja)
- Schild regression (en)
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| - シルトプロット（Schild plot、シルドプロット）は、線型回帰（シルト回帰）を用いてアンタゴニストの薬理学的効力（pA2値）を決定するためのグラフを用いた方法である。名称はに因む。シルトプロットはアンタゴニストのモル濃度の対数（log [Antagonist]）とアンタゴニストの阻害作用（log (r-1) で表わされる）との間の線型関係を描写する。 シルトプロットの回帰線は特に重要であり、傾きは拮抗作用の性質に関する情報を与える。回帰線の横軸切片はアンタゴニストの効力（pA2値）に対応する。 (ja)
- Der Schild-Plot ist ein nach Heinz Otto Schild benanntes grafisches Verfahren zur Ermittlung der pharmakologischen Wirkpotenz eines Antagonisten (pA2-Wert) unter Nutzung der Linearen Regression (Schild-Regression). Der Schild-Plot beschreibt dabei den linearen Zusammenhang zwischen dem Logarithmus der molaren Antagonistenkonzentration (log [Antagonist]) und der Hemmwirkung des Antagonisten (dargestellt als log (r-1)): (de)
- In pharmacology, Schild regression analysis, named for Heinz Otto Schild, is a tool for studying the effects of agonists and antagonists on the response caused by the receptor or on ligand-receptor binding. where
* r is the dose ratio
* is the concentration of the antagonist
* is the equilibrium constant of the binding of the antagonist to the receptor A Schild plot is a double logarithmic plot, typically as the ordinate and as the abscissa. This is done by taking the base-10 logarithm of both sides of the previous equation after subtracting 1: (en)
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| - A straight line graph fitted to hypothetical points. The Schild plot of a reversible competitive antagonist should be a straight line, with linear gradient, whose y-intercept relates to the strength of the antagonist. (en)
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| - Der Schild-Plot ist ein nach Heinz Otto Schild benanntes grafisches Verfahren zur Ermittlung der pharmakologischen Wirkpotenz eines Antagonisten (pA2-Wert) unter Nutzung der Linearen Regression (Schild-Regression). Der Schild-Plot beschreibt dabei den linearen Zusammenhang zwischen dem Logarithmus der molaren Antagonistenkonzentration (log [Antagonist]) und der Hemmwirkung des Antagonisten (dargestellt als log (r-1)): Besondere Bedeutung besitzt die Regressionsgerade im Schild-Plot. Ihre Steigung liefert Aussagen über die Art des Antagonismus. Die antagonistische Potenz (pA2-Wert) entspricht dem Abszissenschnittpunkt der Regressionsgeraden. (de)
- In pharmacology, Schild regression analysis, named for Heinz Otto Schild, is a tool for studying the effects of agonists and antagonists on the response caused by the receptor or on ligand-receptor binding. Dose-response curves can be constructed to describe response or ligand-receptor complex formation as a function of the ligand concentration. Antagonists make it harder to form these complexes by inhibiting interactions of the ligand with its receptor. This is seen as a change in the dose response curve: typically a rightward shift or a lowered maximum. A reversible competitive antagonist should cause a rightward shift in the dose response curve, such that the new curve is parallel to the old one and the maximum is unchanged. This is because reversible competitive antagonists are surmountable antagonists. The magnitude of the rightward shift can be quantified with the dose ratio, r. The dose ratio r is the ratio of the dose of agonist required for half maximal response with the antagonist present divided by the agonist required for half maximal response without antagonist ("control"). In other words, the ratio of the EC50s of the inhibited and un-inhibited curves. Thus, r represents both the strength of an antagonist and the concentration of the antagonist that was applied. An equation derived from the Gaddum equation can be used to relate r to , as follows: where
* r is the dose ratio
* is the concentration of the antagonist
* is the equilibrium constant of the binding of the antagonist to the receptor A Schild plot is a double logarithmic plot, typically as the ordinate and as the abscissa. This is done by taking the base-10 logarithm of both sides of the previous equation after subtracting 1: This equation is linear with respect to , allowing for easy construction of graphs without computations. This was particular valuable before the use of computers in pharmacology became widespread. The y-intercept of the equation represents the negative logarithm of and can be used to quantify the strength of the antagonist. These experiments must be carried out on a very wide range (therefore the logarithmic scale) as the mechanisms differ over a large scale, such as at high concentration of drug. The fitting of the Schild plot to observed data points can be done with regression analysis. (en)
- シルトプロット（Schild plot、シルドプロット）は、線型回帰（シルト回帰）を用いてアンタゴニストの薬理学的効力（pA2値）を決定するためのグラフを用いた方法である。名称はに因む。シルトプロットはアンタゴニストのモル濃度の対数（log [Antagonist]）とアンタゴニストの阻害作用（log (r-1) で表わされる）との間の線型関係を描写する。 シルトプロットの回帰線は特に重要であり、傾きは拮抗作用の性質に関する情報を与える。回帰線の横軸切片はアンタゴニストの効力（pA2値）に対応する。 (ja)
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