Sandra Pupatello (née Pizzolitto; born October 6, 1962) is a politician in Ontario, Canada. She served in the Legislative Assembly of Ontario from 1995 to 2011 as a member of the Ontario Liberal Party, serving as a Minister in the government of Dalton McGuinty. She did not run in the 2011 provincial election and took a position as director of business and global markets at PricewaterhouseCoopers. On November 8, 2012, Pupatello announced her candidacy for the leadership of the Liberal Party of Ontario. On January 26, 2013, she lost to Kathleen Wynne on the third and final ballot. Afterwards, she returned to PricewaterhouseCoopers. Pupatello served as chair of Hydro One from 2014 to 2015.