Preclinical or small-animal Single Photon Emission Computed Tomography (SPECT) is a radionuclide based molecular imaging modality for small laboratory animals (e.g. mice and rats). Although SPECT is a well-established imaging technique that is already for decades in use for clinical application, the limited resolution of clinical SPECT (~10 mm) stimulated the development of dedicated small animal SPECT systems with sub-mm resolution. Unlike in clinics, preclinical SPECT outperforms preclinical coincidence PET in terms of resolution (best spatial resolution of SPECT - 0.25mm, PET ≈ 1 mm ) and, at the same time, allows to perform fast dynamic imaging of animals (less than 15s time frames).
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