Pontso S. M. Sekatle (born 26 May 1957) is a politician and academic in Lesotho. Sekatle lectured at the National University of Lesotho from 1984 to 2001. In June 2001, she was appointed to the Senate of Lesotho, and on July 6, 2001 she became Minister of Health and Social Welfare. She was a member of the Qacha's Nek constituency for third time with the win in the elections in 2012 and was appointed the Minister of Local government and Chieftainship Affairs.