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About: O6-Benzylguanine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatExperimentalCancerDrugs, within Data Space : dbpedia.org associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceChemical compoundyago:WikicatAntineoplasticDrugsyago:WikicatMolecularFormulasyago:Abstraction100002137yago:Agent114778436yago:Antineoplastic102722458yago:CausalAgent100007347yago:Communication100033020yago:CytotoxicDrug103157987yago:Drug103247620yago:Formula106816935yago:Matter100020827yago:Medicine103740161yago:Message106598915yago:MolecularFormula106817173yago:PhysicalEntity100001930chemical compoundyago:Statement106722453yago:Substance100020090yago:WikicatExperimentalCancerDrugs New Facet based on Instances of this Class

O6-Benzylguanine (O6-BG) is a synthetic derivative of guanine. It is an antineoplastic agent. It exerts its effect by acting as a suicide inhibitor of the enzyme O6-alkylguanine-DNA alkyltransferase which leads to interruption of DNA repair. O6-BG was used clinically in combination with the alkylating agent temozolomide for glioblastoma, however the combination was found to be overly toxic without adding significant benefit. O6-BG is also used as a biochemical tool in the study of DNA repair mechanisms.