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About: N-Glycolylneuraminic acid     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:Unit109465459, within Data Space : dbpedia.org associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceChemical compoundyago:WikicatCarboxylicAcidsyago:WikicatMolecularFormulasyago:WikicatMonosaccharidesyago:WikicatSugarAcidsyago:Abstraction100002137yago:Acid114607521yago:Carbohydrate114792703yago:CarboxylicAcid114739360yago:Chemical114806838yago:Communication100033020yago:Compound114818238yago:Formula106816935yago:Macromolecule114944888yago:Material114580897yago:Matter100020827yago:Message106598915yago:MolecularFormula106817173yago:Molecule114682133yago:Monosaccharide114954284yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:Relation100031921chemical compoundyago:Statement106722453yago:Substance100019613yago:Thing100002452yago:Unit109465459 New Facet based on Instances of this Class

N-Glycolylneuraminic acid (Neu5Gc) is a sialic acid molecule found in most non-human mammals. Humans cannot synthesize Neu5Gc because the human gene CMAH is irreversibly mutated, though it is found in other apes. It is absent in human tissues because of inactivation of gene encoding CMP-N-acetylneuraminic acid hydroxylase. The gene CMAH encodes for CMP-N-acetylneuraminic acid hydroxylase, which is the enzyme responsible for CMP-Neu5Gc from CMP-N-acetylneuraminic (CMP-Neu5Ac) acid. This loss of CMAH is estimated to have occurred 2-3 million years ago, just before the emergence of the genus Homo.