Route 48 is a state highway in northwestern Missouri. Its western terminus is located at U.S. Route 71 (US 71) north of Savannah. The route travels eastward across the communities of Rosendale, Rea, and Whitesville. The road ends at US 169 in King City, about 20 miles (32 km) from its western terminus. The road was designated around 1926, and was completely laid down with gravel by 1936 and paved in asphalt by 1942.