Route 21 is a highway in eastern Missouri. Its northern terminus is at Route 30 in Affton. Its southern terminus is at the Arkansas state line (where it continues as Highway 115). In the St. Louis area, it is known as Tesson Ferry Road, which was named after the 19th century proprietor of the ferry across the Meramec River. Route 21 from the Meramec River to Route B, along with Route M, make up the Jefferson County Scenic Byway.