Jan Cornelis Maria van Hest (born 28 September 1968) is a Dutch scientist of organic chemistry, best known for his research regarding polymersomes and nanoreactors. He currently holds the position of professor of bioorganic chemistry at Eindhoven University of Technology and is scientific director at the Institute of Complex Molecular Systems. Among the awards he has received, he was one of the recipients of the 2020 Spinoza Prize.