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Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide (CO2). GAD uses pyridoxal-phosphate (PLP) as a cofactor. The reaction proceeds as follows: HOOC−CH2−CH2−CH(NH2)−COOH → CO2 + HOOC−CH2−CH2−CH2NH2 Several truncated transcripts and polypeptides of GAD67 are detectable in the developing brain, however their function, if any, is unknown.

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  • Glutamát dekarboxyláza (cs)
  • Glutamat-Decarboxylase (de)
  • Glutamate decarboxylase (en)
  • Glutamate décarboxylase (fr)
  • グルタミン酸デカルボキシラーゼ (ja)
  • Glutamato descarboxilase (pt)
  • Глутаматдекарбоксилаза (ru)
  • Glutaminsyradekarboxylas (sv)
  • 谷氨酸脱羧酶 (zh)
rdfs:comment
  • グルタミン酸デカルボキシラーゼ、グルタミン酸脱炭酸酵素(Glutamate decarboxylase, glutamic acid decarboxylase: GAD)は、グルタミン酸を脱炭酸する酵素の一種。分子量の違う、GAD67(GAD1)とGAD65(GAD2)の2種類が存在する。この酵素の働きにより、グルタミン酸はGABAと二酸化炭素に分解される。 (ja)
  • Glutaminsyradekarboxylas (GAD) är ett enzym som katalyserar omvandlingen av aminosyran glutaminsyra (egentligen dess anjon, glutamat) till signalsubstansen GABA och koldioxid. Eftersom koldioxid spjälkas loss är reaktionen en dekarboxylering. GAD använder som koenzym. Reaktionen sker enligt: HOOC-CH2-CH2-CH(NH2)-COOH → CO2 + HOOC-CH2-CH2-CH2NH2Glutaminsyra → Koldioxid + GABA Hos däggdjur finns GAD i två liknande former som kodas av två olika gener, Gad1 och Gad2. är GAD67 och GAD65.Gad1 och Gad2 uttrycks i hjärnan där GABA används som signalsubstans, Gad2 uttrycks också i bukspottkörteln. (sv)
  • 谷氨酸脱羧酶（英語：Glutamate decarboxylase；GAD）是一个催化谷氨酸脱羧为γ-氨基丁酸并释放CO2的酶。此酶使用磷酸吡哆醛作为一个辅因子。此反应以如下方式进行： HOOC-CH2-CH2-CH(NH2)-COOH → CO2 + HOOC-CH2-CH2-CH2NH2 此酶在哺乳动物中存在着两种，它们分别由两种不同的基因——Gad1与Gad2编码。这些亚型分别是GAD67与GAD65，分子量分别为67与65千道尔顿。GAD1与GAD2在大脑中被表达出来，在此处γ-氨基丁酸被用于作为神经递质，GAD2也会在胰腺中被表达出来。 至少有两种更多的类型，GAD25与GAD44（胎儿；EGAD）被发现于发育中的大脑中。 (zh)
  • Glutamát dekarboxyláza nebo dekarboxyláza kyseliny glutamové (GAD) je enzym , který katalyzuje dekarboxylaci glutamátu na GABA a CO2. GAD používá PLP jako kofaktor. Reakce probíhá takto: HOOC-CH2-CH2-CH(NH2)-COOH → CO2 + HOOC-CH2-CH2-CH2NH2 Několik zkrácené přepisy a polypeptidy GAD67 byly nalezeny v vyvíjejícím se mozku, nicméně jejich funkce není známa. (cs)
  • Glutamat-Decarboxylase (GAD) ist ein Enzym in Eukaryoten, das die Decarboxylierung von Glutamat zu γ-Aminobuttersäure (GABA) und CO2 katalysiert. Dies ist der einzige Weg zur Biosynthese des Neurotransmitters GABA. Als Co-Faktor verwendet die Glutamat-Decarboxylase Pyridoxalphosphat. Im Mensch sind zwei Gene bekannt, die für Enzyme mit dieser Aktivität codieren: GAD1 und GAD2. Mutationen im GAD1-Gen können zum Enzymmangel im Gehirn, und dieser zu spastischer tetraplegischer Zerebralparese Typ 1 (CPSQ1), führen. (de)
  • Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide (CO2). GAD uses pyridoxal-phosphate (PLP) as a cofactor. The reaction proceeds as follows: HOOC−CH2−CH2−CH(NH2)−COOH → CO2 + HOOC−CH2−CH2−CH2NH2 Several truncated transcripts and polypeptides of GAD67 are detectable in the developing brain, however their function, if any, is unknown. (en)
  • La glutamate décarboxylase ou acide glutamique décarboxylase (en anglais, glutamic acid decarboxylase ou GAD) est une lyase qui catalyse la réaction : HOOC-CH2-CH2-CH(NH2)-COOH HOOC-CH2-CH2-CH2NH2 + CO2. Cette enzyme réalise donc la conversion du L-glutamate en γ-aminobutyrate (GABA) avec dégagement de dioxyde de carbone. Des anticorps dirigés contre l'enzyme causent en particulier une atteinte auto-immune du cervelet et du pancréas (fr)
  • Glutamato descarboxilase ou descarboxilase do ácido glutâmico (DAG) (também GAD do inglês glutamic acid decarboxylase) é uma enzima que catalisa a descarboxilação do glutamato para AGAB e CO2. A DAG usa o como cofator. A reação processa-se como segue: HOOC-CH2-CH2-CH(NH2)-COOH → CO2 + HOOC-CH2-CH2-CH2NH2 (pt)
  • Глутаматдекарбоксилаза (англ. Glutamate decarboxylase, GAD, GAD65, GAD67, шифр КФ 4.1.1.15) — фермент, катализирующий преобразование глутамата в ГАМК посредством декарбоксилирования по следующей реакции: HOOC-CH2-CH2-CH(NH2)-COOH → CO2 + HOOC-CH2-CH2-CH2NH2. Кофактором GAD является пиридоксальфосфат. (ru)
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  • glutamate decarboxylase (en)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/GAD67_active_site.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/MouseGad65ThGad67.jpg
  • http://commons.wikimedia.org/wiki/Special:FilePath/PDB_GAD67.jpg
  • http://commons.wikimedia.org/wiki/Special:FilePath/PH_conformational_changes.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/Stiff_man_human_cerebellum.jpg
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