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About: B10 cell     Goto   Sponge   NotDistinct   Permalink

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B10 cells are a sub-class of Regulatory B-cell (Breg cell) that are involved in inhibiting immune responses in both humans and mice. B10 cells are named for their ability to produce inhibitory interleukin: Interleukin-10 (IL-10). One of their unique abilities is that they suppress the innate and adaptive immune signals, making them important for regulating the inflammatory response. Like the B-cell, the B10 cell requires antigen specific binding to the surface of CD5 receptor to illicit a response from the T-cell. Once an antigen binds to the CD19 receptor, immediate downregulation in B-cell antigen receptor (BCR) signal expression occurs and mediates the release of IL-10 cytokines.