Ancestim is a recombinant methionyl human stem cell factor, branded by Amgen as StemGen. It was developed by Amgen and sold to Biovitrium, now Swedish Orphan Biovitrum, in December, 2008. It is a 166 amino acid protein produced by E. coli bacteria into which a gene has been inserted for soluble human stem cell factor. It has a monomeric molecular weight of approximately 18,500 daltons and normally exists as a noncovalently associated dimer. The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine retained after expression in E. coli. Because Ancestim is produced in E. coli, it is nonglycosylated. Ancestim is supplied as a sterile, white, preservative-free, lyophilised pow
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- Ancestim (en)
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| - أنسستيم هو عامل الخلية الجذعية بشري مأشوب بالميثيونيل، سوقته أمجن تحت تسم تجاري هو StemGen. طورته في الأصل أمجن ثم باعته في ديسمبر 2008 إلى بايوفيتروم، والتي هي حاليا جزء من سويدش أورفان بايوفيتروم. الدواء عبارة عن بروتين يتكون من 166 حمض أميني تنتجه بكتيريا الإشريكية القولونية التي أدخل فيها جين لعامل الخلية الجذعية البشري الذائب. يتوفر أنسستيم في شكل مسحوق مجفف بالتجميد نبيذ أبيض خال من المواد الحافظة تحقن تحت الجلد يستعمل مع فيلغراستيم لتحشيد الخلايا الجذعية المكونة للدم لغرض زراعتها لاحقا في أنواع معينة من مرض السرطان. (ar)
- Ancestim is a recombinant methionyl human stem cell factor, branded by Amgen as StemGen. It was developed by Amgen and sold to Biovitrium, now Swedish Orphan Biovitrum, in December, 2008. It is a 166 amino acid protein produced by E. coli bacteria into which a gene has been inserted for soluble human stem cell factor. It has a monomeric molecular weight of approximately 18,500 daltons and normally exists as a noncovalently associated dimer. The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine retained after expression in E. coli. Because Ancestim is produced in E. coli, it is nonglycosylated. Ancestim is supplied as a sterile, white, preservative-free, lyophilised pow (en)
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| - s.c. injection only, premedication with H1 and H2 antihistamines and beta-receptor agonists for bronchodilation (en)
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| - أنسستيم هو عامل الخلية الجذعية بشري مأشوب بالميثيونيل، سوقته أمجن تحت تسم تجاري هو StemGen. طورته في الأصل أمجن ثم باعته في ديسمبر 2008 إلى بايوفيتروم، والتي هي حاليا جزء من سويدش أورفان بايوفيتروم. الدواء عبارة عن بروتين يتكون من 166 حمض أميني تنتجه بكتيريا الإشريكية القولونية التي أدخل فيها جين لعامل الخلية الجذعية البشري الذائب. يتوفر أنسستيم في شكل مسحوق مجفف بالتجميد نبيذ أبيض خال من المواد الحافظة تحقن تحت الجلد يستعمل مع فيلغراستيم لتحشيد الخلايا الجذعية المكونة للدم لغرض زراعتها لاحقا في أنواع معينة من مرض السرطان. (ar)
- Ancestim is a recombinant methionyl human stem cell factor, branded by Amgen as StemGen. It was developed by Amgen and sold to Biovitrium, now Swedish Orphan Biovitrum, in December, 2008. It is a 166 amino acid protein produced by E. coli bacteria into which a gene has been inserted for soluble human stem cell factor. It has a monomeric molecular weight of approximately 18,500 daltons and normally exists as a noncovalently associated dimer. The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine retained after expression in E. coli. Because Ancestim is produced in E. coli, it is nonglycosylated. Ancestim is supplied as a sterile, white, preservative-free, lyophilised powder for reconstitution and administration as a subcutaneous (SC) injection and is indicated for use in combination with filgrastim for mobilizing peripheral hematopoietic stem cells for later transplantation in certain cancer patients. (en)
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