The 2022 NCAA Division I women's basketball championship game was the final game of the 2022 NCAA Division I women's basketball tournament. It determined the national champion for the 2021–22 season, and was contested by the UConn Huskies and the South Carolina Gamecocks. The game was played on April 3, 2022, at the Target Center in Minneapolis, Minnesota. In the game, the Gamecocks jumped out to an 18-point lead early in the second quarter and held off UConn scoring runs to win the national championship, 64–49. South Carolina's Aliyah Boston was voted the NCAA Tournament Most Outstanding Player (MOP). This was UConn's first loss in the women's national championship game.