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GRL-0617 is a drug which is one of the first compounds discovered that acts as a selective small-molecule inhibitor of the protease enzyme papain-like protease (PLpro) found in some pathogenic viruses, including the coronavirus SARS-CoV-2. It has been shown to inhibit viral replication in vitro.

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  • GRL-0617 (en)
  • GRL-0617 (es)
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  • GRL-0617 is a drug which is one of the first compounds discovered that acts as a selective small-molecule inhibitor of the protease enzyme papain-like protease (PLpro) found in some pathogenic viruses, including the coronavirus SARS-CoV-2. It has been shown to inhibit viral replication in vitro. (en)
  • GRL-0617 es un fármaco que es uno de los primeros compuestos descubiertos que actúa como un inhibidor selectivo de molécula pequeña de la proteasa enzima, proteasa similar a la papaína (PLpro) que se encuentra en algunos virus patógenos, incluido el coronavirus SARS-CoV-2. Se ha demostrado que inhibe la replicación viral «in vitro».​​​​ (es)
foaf:name
  • GRL-0617 (en)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/GRL-0617_structure.png
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drug name
  • GRL-0617 (en)
DrugBank
  • DB08656 (en)
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IUPAC name
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PubChem
SMILES
  • CC1=CCN[C@H]C2=CC=CC3=CC=CC=C32 (en)
StdInChI
StdInChIKey
  • UVERBUNNCOKGNZ-CQSZACIVSA-N (en)
UNII
  • GRL-0617 (en)
has abstract
  • GRL-0617 is a drug which is one of the first compounds discovered that acts as a selective small-molecule inhibitor of the protease enzyme papain-like protease (PLpro) found in some pathogenic viruses, including the coronavirus SARS-CoV-2. It has been shown to inhibit viral replication in vitro. (en)
  • GRL-0617 es un fármaco que es uno de los primeros compuestos descubiertos que actúa como un inhibidor selectivo de molécula pequeña de la proteasa enzima, proteasa similar a la papaína (PLpro) que se encuentra en algunos virus patógenos, incluido el coronavirus SARS-CoV-2. Se ha demostrado que inhibe la replicación viral «in vitro».​​​​ (es)
IUPHAR ligand
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CAS number
  • 1093070-16-6
ChEBI
  • 167176
ChEMBL
  • 549695
DrugBank
  • DB08656
FDA UNII code
  • GRL-0617
PubChem
  • 24941262
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