About: Cytolethal distending toxin

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Cytolethal distending toxins (abbreviated CDTs) are a class of heterotrimeric toxins produced by certain gram-negative bacteria that display DNase activity. These toxins trigger G2/M cell cycle arrest in specific mammalian cell lines, leading to the enlarged or distended cells for which these toxins are named. Affected cells die by apoptosis.

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rdf:type	Thing Biomolecule Biomolecule Protein yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity protein yago:SocialGroup107950920 yago:Unit108189659
rdfs:label	Cytolethal distending toxin (en) Cytolethal distending Toxin (de)
rdfs:comment	Cytolethal distending Toxin (Cdt, zu deutsch etwa “zelltödliches schwellendes Toxin”) ist ein Protein aus verschiedenen Gram-negativen Bakterien und ein mikrobielles Exotoxin. (de) Cytolethal distending toxins (abbreviated CDTs) are a class of heterotrimeric toxins produced by certain gram-negative bacteria that display DNase activity. These toxins trigger G2/M cell cycle arrest in specific mammalian cell lines, leading to the enlarged or distended cells for which these toxins are named. Affected cells die by apoptosis. (en)
name	Cytolethal distending toxin (en)
foaf:depiction
dcterms:subject	Toxins
Wikipage page ID	32240777 (xsd:integer)
Wikipage revision ID	1107324951 (xsd:integer)
Link from a Wikipage to another Wikipage	Campylobacterota Pseudomonadota Enterocolitis Pathogenic Pathogens Peptide Dysentery In vitro In vivo Salmonella enterica Endothelial cells Gammaproteobacteria Operon Phosphodiester bonds Apoptosis Lymphocytes Haemophilus ducreyi Aggregatibacter actinomycetemcomitans Toxins Typhoid fever Gram-negative Toxins E. coli Escherichia coli (molecular biology) Cell cycle Gram-negative bacteria Fibroblasts AB toxin Keratinocytes Homology (biology) Protein trimer Mitosis DNase DNase I H. ducreyi Campylobacter jejuni Campylobacter upsaliensis Chancroid Shigella dysenteriae Alkaline phosphatase Phylum Periodontal disease Shigella Molecular Microbiology Point mutations Epithelial cells Cell lines AB-type toxins AB toxins Hetero Genotoxins dbr:Wikt:tripartite
sameAs	Cytolethal distending toxin Cytolethal distending toxin Cytolethal distending toxin Cytolethal distending toxin
dbp:wikiPageUsesTemplate	dbt:Infobox_protein_family dbt:Reflist
thumbnail	wiki-commons:Special:FilePath/PDB_protein_1sr4_(HdCDT).jpg?width=300
caption	Crystal structure of the fully assembled Haemophilus ducreyi cytolethal distending toxin (en)
InterPro	IPR003558 (en)
Pfam	PF03498 (en)
Pfam clan	CL0066 (en)
symbol	CDT (en)
has abstract	Cytolethal distending Toxin (Cdt, zu deutsch etwa “zelltödliches schwellendes Toxin”) ist ein Protein aus verschiedenen Gram-negativen Bakterien und ein mikrobielles Exotoxin. (de) Cytolethal distending toxins (abbreviated CDTs) are a class of heterotrimeric toxins produced by certain gram-negative bacteria that display DNase activity. These toxins trigger G2/M cell cycle arrest in specific mammalian cell lines, leading to the enlarged or distended cells for which these toxins are named. Affected cells die by apoptosis. Each toxin consists of three distinct subunits named alphabetically in the order that their coding genes appear in the cdt operon. Cytolethal distending toxins are classified as AB toxins, with an active ("A") subunit that directly damages DNA and a binding ("B") subunit that helps the toxin attach to the target cells. CdtB is the active subunit and a homolog to mammalian DNase I, whereas CdtA and CdtC make up the binding subunit. Cytolethal distending toxins are produced by gram-negative pathogenic bacteria from the phylum Pseudomonadota. Many of these bacteria, including Shigella dysenteriae, Haemophilus ducreyi, and Escherichia coli, infect humans. Bacteria that produce CDTs often persistently colonize their host. (en)
gold:hypernym	Toxins
prov:wasDerivedFrom	wikipedia-en:Cytolethal_distending_toxin?oldid=1107324951&ns=0
page length (characters) of wiki page	15718 (xsd:nonNegativeInteger)
Symbol	CDT
foaf:isPrimaryTopicOf	wikipedia-en:Cytolethal_distending_toxin
is Link from a Wikipage to another Wikipage of	Aggregatibacter actinomycetemcomitans Irritable bowel syndrome Campylobacter Campylobacter upsaliensis CDT Migrating motor complex

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