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- Cytolethal distending Toxin (Cdt, zu deutsch etwa “zelltödliches schwellendes Toxin”) ist ein Protein aus verschiedenen Gram-negativen Bakterien und ein mikrobielles Exotoxin. (de)
- Cytolethal distending toxins (abbreviated CDTs) are a class of heterotrimeric toxins produced by certain gram-negative bacteria that display DNase activity. These toxins trigger G2/M cell cycle arrest in specific mammalian cell lines, leading to the enlarged or distended cells for which these toxins are named. Affected cells die by apoptosis. Each toxin consists of three distinct subunits named alphabetically in the order that their coding genes appear in the cdt operon. Cytolethal distending toxins are classified as AB toxins, with an active ("A") subunit that directly damages DNA and a binding ("B") subunit that helps the toxin attach to the target cells. CdtB is the active subunit and a homolog to mammalian DNase I, whereas CdtA and CdtC make up the binding subunit. Cytolethal distending toxins are produced by gram-negative pathogenic bacteria from the phylum Pseudomonadota. Many of these bacteria, including Shigella dysenteriae, Haemophilus ducreyi, and Escherichia coli, infect humans. Bacteria that produce CDTs often persistently colonize their host. (en)
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- Crystal structure of the fully assembled Haemophilus ducreyi cytolethal distending toxin (en)
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- Cytolethal distending toxin (en)
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- Cytolethal distending Toxin (Cdt, zu deutsch etwa “zelltödliches schwellendes Toxin”) ist ein Protein aus verschiedenen Gram-negativen Bakterien und ein mikrobielles Exotoxin. (de)
- Cytolethal distending toxins (abbreviated CDTs) are a class of heterotrimeric toxins produced by certain gram-negative bacteria that display DNase activity. These toxins trigger G2/M cell cycle arrest in specific mammalian cell lines, leading to the enlarged or distended cells for which these toxins are named. Affected cells die by apoptosis. (en)
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- Cytolethal distending toxin (en)
- Cytolethal distending Toxin (de)
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